Daniel Tillia is a research optometrist at the Brien Holden Vision Institute, a part-time clinical supervisor at the School of Optometry and Vision Science, University of New South Wales, Australia, and occasionally works in private practice.Download the poster (.pdf), which was originally shared at the British Contact Lens Association’s Clinical Conference and Exhibition, 2012
Associations between solution induced corneal staining, corneal infiltrative events, and Gram negative bacteria case contamination
1Daniel Tilia, M.Optom, 1Hua Zhu, Ph.D, 1Varghese Thomas, B.Sc, 2Mark Wilcox, Ph.D, 2,3Brien Holden, Ph.D, 1,2Percy Lazon de la Jara, Ph.D
1Brien Holden Vision Institute, University of New South Wales, Sydney, Australia;2School of Optometry and Vision Science, University of New South Wales, Sydney, Australia; 3Vision Cooperative Research Centre, Sydney, Australia.
Corresponding Author: d.tília@brienholdenvision.org
Purpose: To compare incidences of solution induced corneal staining (SICS), corneal infiltrative events (CIEs) and Gram-negative bacteria case contamination (GNBCC) rates between five lens care products (LCPS) when used with the same silicone hydrogel contact lens.
Method: Rates for SICS, CIE and GNBCC for LCPs (AOSEPT Plus [AOSP]: H202, CIBA; Synergi: sodium chloríte/H202, Sauflon; Complete RevítaLens MPDS [CRL]: polyqyaternium-1/alexidine dihydroschloride, AMO; Biotrue: polyquaternium1/PHMB, B+L;, AQuífy: PHMB, CIBA) when used with balafilcon A (B+L) lenses were obtained either from published data or calculated retrospectively. All studies followed a similar protocol. SICS and CIE incidences were reported as occurrence per 100 participant-months. Analysed cases were used for one month and number colony forming units of GNB counted after culture. Antìbacterìal cases were used with Synergì, polypropylene with CRL, Bìotrue and AQuify. Rates were compared using Fìsher’s exact test with Bonferroni adjustment for multiple comparisons. Statistical significance was set at p<0.05.
Results: Percentage rates for SICS/CIE/GNBCC for each LCP were AOSP: 0.9/0/-, Synergi: 0.9/0/1/4, CRL: 5.1/0/11.8, Biotrue: 29.0/1.8/15.9, AQuify: 21.9/4.0/28.8. The oxidative LCPs (AOSP/Synergi) were significantly lower than PHMB containing LCPs for SICS (0.9%v25.6%, p<0.001), CIEs (0%v2.8%, p=0.01) and GNBCC (1.4%v21.9%, p<0.001). Oxidative LCPs were significantly lower and the alexidine containing LCP for SICS (5.1%, p=0.04) and GNBCC (Synergi only)(11.8%, p=0.02) but not CIEs (0%, p>0.05). The alexidine LCP was significantly lower than PHMB LCPs for SICS (p<0.001) but not CIEs (p>0.05) or GNBCC (p>0.05).
Conclusions: When used with balafilcon A, oxidative LCPs have lower rates of SICS. Efficacy against GNBCC might reduce CIE incidence.
