• About Us
  • Privacy
  • Contact Us

Contact Lens Update

Clinical Insights Based in Current Research

Search Our Site

  • Home
  • Browse Past Issues
  • Resource Library
  • Back to Basics
  • Useful Links
  • About Us
  • Contact Us

Conference Highlights

Ocular delivery of ketotifen fumarate by silicone hydrogel and conventional hydrogel contact lens materials

June 29th, 2012
Anthony Soluri, HBSc is an optometry student at the University of Waterloo School of Optometry and Vision Science and researching drug delivery via contact lenses at the Centre for Contact Lens Research.

Download the poster (.pdf), which was originally shared at the Association for Research in Vision & Ophthalmology (ARVO) annual meeting, 2012.


 

Ocular delivery of ketotifen fumarate by silicone hydrogel and conventional hydrogel contact lens materials

Anthony Soluri, HBSc, Alex Hui, OD, and Lyndon Jones, PhD

Centre for Contact Lens Research, School of Optometry, University of Waterloo

Objectives: To investigate the uptake and delivery of the anti-allergy drug ketotifen fumarate (KF), by commercially available contact lenses.

Methods: A total of fourteen different commercially available contact lenses were investigated, including five frequent replacement silicone hydrogels (balafilcon A, comfilcon A, galyfilcon A, senofilcon A and lotrafilcon B), three conventional hydrogels (alphafilcon A, etafilcon A, and polymacon) and six daily disposable lenses (nelfilcon A, omafilcon A, etafilcon A + PVP, ocufilcon B, narafilcon A and filcon II 3). Lenses were soaked in a 0.025% KF loading solution for 24 hours, and the concentration of KF in solution over time was determined by UV absorbance at 297 nm. After the 24 hour loading period, lenses were placed into fresh vials containing borate buffered saline (BBS), and the release of drug into solution at 34°C was monitored over 24 hours.

Results: All the lenses studied demonstrated significant uptake and release of KF into the BBS (p<0.05 compared to initial time point). Lenses with charged surfaces (balafilcon A, etafilcon A and etafilcon A + PVP) demonstrated the greatest uptake and release of KF. Etafilcon A released 284.5 ± 29.8 µg/lens, while balafilcon A released 227.6 ± 14.7 µg/lens, which was substantially more (p<0.05) than the lowest releasing lenses (nelfilcon A; 40.4 ± 4.1 µg/lens and comfilcon A; 110.4 ± 8.9 µg/lens). The majority of lenses were able to match or exceed the total amount of KF commonly administered to the eye using twice daily dosing of commercially available (0.025%) eye drop formulations. Most of the lenses surveyed released to a plateau concentration of KF relatively quickly, and no lens was able to release KF for longer than four hours.

Conclusions: Commercially available lenses demonstrated the ability to release a clinically relevant amount of KF compared to conventional eye drops. The use of commercially available contact lenses as a KF delivery system in a daily disposable wear scenario may be feasible.

Acknowledgements: Alex Hui is supported by the Natural Sciences and Engineering Research Council (NSERC) of Canada, the Canadian Optometric Education Trust Fund (COETF), and a Vistakon® Research Grant and Ezell Fellowship, both administered by the American Optometric Foundation (AOF). This study is also supported by the NSERC 20/20 Network for the Development of Advanced Ophthalmic Materials.

Related Articles

  • June 29, 2012

    Delivering cyclosporine A from contact lenses: An article review

  • June 29, 2012

    Barriers to drug delivery via contact lenses: A report from the 2012 BCLA meeting

  • June 29, 2012

    Contact lenses for drug delivery – overview and recent developments

  • June 29, 2012

    Ocular delivery of ketotifen fumarate by silicone hydrogel and conventional hydrogel contact lens materials

Issues

  • In-Office Procedures for Dry Eye
  • Multifocal Contact Lenses
  • Artificial Tears: An Update
  • Myopia: New Evidence and Best Practices
  • Neuropathic Pain
  • Specialty Rigid Lenses
  • Contact lens compliance
  • Pandemic update
  • Digital Devices and Dry Eye: A Growing Issue
  • The long and short of axial length
  • Using BCLA CLEAR with your patients
  • Helping your patients through allergy season
  • Getting the measure of meibomian glands
  • 2020: An extraordinary year
  • Scleral lens update
  • A dose of myopia
  • New news since TFOS DEWS II
  • COVID-19 Special Edition
  • Material considerations
  • Putting dry eye theory into practice
  • Getting started with Ortho-K
  • Infiltrates – an update
  • Staining
  • Myopia matters: Summarising the IMI reports
  • Lids and contact lenses
  • Myths
  • Revisiting patient compliance
  • Contact Lenses & Kids
  • Interprofessional Collaboration
  • Digital eye strain
  • New Dry Eye Technology
  • Update on Presbyopia
  • Taking stock of dry eye disease: DEWS II
  • Scleral Lenses
  • Pain and Sensation
  • Lab measurements in clinical practice
  • Control of pediatric myopia
  • Nutrition
  • Rethinking contact lens deposits
  • Extended wear
  • Daily Disposables
  • Eyelash Mites (Demodex)
  • Outsmarting bacteria with new technology
  • Youth and contact lenses
  • Sports Vision
  • Ocular effects of UV radiation from the sun
  • Eyelid Conditions
  • Makeup: Impact on ocular health
  • Myopia Control – Update 2014
  • The Growing Prevalence of Myopia
  • Cosmetic contact lenses
  • Contact lens discomfort – The essentials
  • Technology and contact lens research
  • It's A Question of Comfort
  • Contact lens materials
  • Let's talk about SICS
  • Conjunctival Controversies
  • Kids & Contact Lenses
  • One-day silicone hydrogel lenses
  • Solutions
  • Spotlight on Scleral lenses
  • Drug delivery via contact lenses
  • Ocular allergies
  • Reducing lens case contamination
  • Dry eye and meibomium gland dysfunction
  • Myopia Control
  • Presbyopia
  • Compliance and non-compliance
  • Lens care
  • Celebrating 50 years of contact lenses

Looking for another article?

Alcon coopervision Johnson&Johnson Vision Care

Newsletter Sign-Up

Sign-up for and start receiving our newsletter.

Site Map

  • Home
  • Browse Past Issues
    • Editorial
    • Feature Article
    • Clinical Insight
    • Conference Highlights
  • Resource Library
  • Back to Basics
  • Useful Links
  • About Us
  • Contact Us
© 2023 Contact Lens Update