General definition: unwanted effect(s) (i.e. physical and/or psychological symptoms and signs) resulting from treatment; any undesirable effect or problem that is present during the period of treatment. In contact lens practice, common categories: • Serious adverse reaction = symptomatic adverse reaction of sufficient clinical concern to warrant permanently discontinuing lens wear and that produces or has the potential to produce significant visual impairment. • Significant adverse event = mostly symptomatic adverse reaction of sufficient clinical concern to warrant temporary or permanent discontinuation of lens wear. • Non-significant adverse events = asymptomatic adverse event not of sufficient clinical concern; may not warrant discontinuation of the patient from lens wear.
Regular examination of contact lens patients for extended wear, consisting of at least vision assessment, history and ocular examination with and without the lenses in place using a biomicroscope slit-lamp; recommended schedule for the first appointments after successful lens fitting: 1. @ 24 hours 2. @ one week 3. @ one month 4. @ 3 months Every three months thereafter, additional unscheduled appointments whenever necessary. Also see Emergency care.
Complete deprivation of oxygen, suffocation of the corneal cells, leading to neovascularization and edema.
Corneal condition including the presence of one or more focal infiltrates (clusters of inflammatory cells), less than 0.2mm in size. Asymptomatic infiltrates are commonly seen in the periphery but may be observed anywhere in the cornea. The infiltrates are limited to the anterior stroma and overlying epithelium is intact. Bilateral events are common. The conjunctiva is normal. No symptoms are present and therefore asymptomatic infiltrates are usually only observed at routine aftercare visits. The condition resolves rapidly with no sequelae. Asymptomatic infiltrates are found in lens wearers and non-lens wearers. There is little variation in the incidence with various modes of lens wear.